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Dissertation

Apply the recommendations resulting from our founders dissertation

and experience what you Will achieve

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dissertation

Apply the recommendations

resulting from
our founders dissertation

AND EXPERIENCE

WHAT YOU WILL ACHIEVE

Download here


TOWARDS

A PATIENT-DRIVEN APPROACH TO

ADVERSE EVENTS OF TARGETED AGENTS

IN ONCOLOGY

BY CHRISTINE BETTINE BOERS

AIMS

The central question of this dissertation is whether available methods and instruments can serve as a basis

 for the realization of an

integrated patient-driven approach to targeted therapy-associated adverse events

for the best outcome possible.

Dissertation Attachments

Propositions (EN)

Stellingen (NL)

By Christine Boers-Doets
free of charge

Samenvatting van het proefschrift

door Christine Boers-Doets
gratis

Brief Summary

of the Thesis

By Christine Boers-Doets
free of charge

Implications for research & daily practice

Targeted therapy-associated adverse events should be approached in an integrated, interdisciplinary team model of care and in a systematic fashion.
The co-care model proposed in this thesis offers a framework for this approach in which the three findings in this thesis can be embedded:

Adverse Event Assessment & Grading

Finding: Current adverse event measurement instruments may be of limited value for the assessment, reporting, grading, and evaluation of targeted therapy-associated skin and mucosal reactions. Overall, the incorporation of the patient’s voice is limited.

Solution: The development of a combined 3-part patient-reported assessment and grading instrument that maps the symptoms and signs of an adverse event and their impact on health related quality of life.

7 Levels of Adverse Event Expertise

Finding: The generated scientific adverse event knowledge that has become available is not imbedded broadly in clinical and research practice.

Solution: Establishing training programs for healthcare providers especially for those involved in clinical trials and those who work on a daily basis with patients on targeted therapies is indicated.

A patient-driven approach to

adverse events

Finding: Research and practice  show that adverse events due to targeted treatments can cause the therapy to be temporarily interrupted, a dose reduction applied, or treatment to be discontinued prematurely, despite its effective anticancer effect.
Solution: Targeted therapy-associated adverse events should be approached in an integrated, interdisciplinary team model of care and in a systematic fashion. The co-care model proposed in this thesis offers a framework for this approach in which the three findings in this thesis can be embedded.

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